MRPMedical Research and Practice2993-96902993-9704Art and Technology10.61369/MRP.8050Article真人养脏汤核心成分治疗溃疡性结肠炎的网络药理学研究https://artdesignp.com/journal/MRP/2/8/10.61369/MRP.8050叶梦琪2024282024-08-20目的：采用网络药理学方法研究真人养脏汤治疗溃疡性结肠炎（UC）的作用机制。方法：在相关数据库中筛选真人养脏汤的有效成分和潜在靶点，构建化合物－靶点网络。然后筛选UC的靶点，得出共同的靶点，形成PPI网络用于预测核心的靶点。并对所得到的结果进行GO 和KEGG富集分析。结果：共预测了6种有效成分和77个共同靶点。山萘酚，Β-谷甾醇，玫瑰树碱，鞣花酸，豆固醇，异癸酸为药物关键有效活性成分，作用机制可能与癌症信号通路、脂质与动脉粥样硬化通路、化学致癌－受体激活通路、乙肝通路、人类疱疹病毒第四型感染通路、人类免疫缺陷病毒感染通路等信号通路有关。HSP90AA1、MAPK8、TNF、CASP3是UC治疗的关键靶点。结论。本研究体现了ZRYZ多成分、多靶点、多通路治疗溃疡性结肠炎的复杂网络关系，为治疗UC提供了思路。溃疡性结肠炎 ,真人养脏汤 ,网络药理学

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