<?xml version="1.1" encoding="utf-8"?>
<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">MRP</journal-id><journal-title-group><journal-title>Medical Research and Practice</journal-title></journal-title-group><issn>2993-9690</issn><eissn>2993-9704</eissn><publisher><publisher-name>Art and Technology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/MRP.8030</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>阿德福韦酯致范科尼综合征合并低磷性骨软化症及代谢性酸中毒1例报告</title><url>https://artdesignp.com/journal/MRP/2/8/10.61369/MRP.8030</url><author>滕曼,王艳,罗娜,曹灵,张真稳</author><pub-date pub-type="publication-year"><year>2024</year></pub-date><volume>2</volume><issue>8</issue><history><date date-type="pub"><published-time>2024-08-20</published-time></date></history><abstract>范科尼综合征是近端肾小管复合型功能缺陷引起多种溶质随尿排泄过多而导致的临床综合征，临床突出表现为：尿液出现过量氨基酸、葡萄糖、磷酸盐、碳酸盐、尿酸盐等，内环境则出现低血磷、低血钾、低血钙、低尿酸及酸中毒，以及骨软化、骨质疏松等骨骼病变。而药物引起的范可尼综合征可能被忽视或误诊，这增加了病人的痛苦的程度。我院收治1例阿德福韦酯致范科尼综合征合并低磷性骨软化症及代谢性酸中毒，应引起临床重视。</abstract><keywords>阿德福韦酯 ,范科尼综合征 ,低磷性骨软化症 ,代谢性酸中毒</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>[1] Wu C, Zhang H, Qian Y, et al. Hypophosphatemic osteomalacia and renal Fanconi syndrome induced by low-dose adefovir dipivoxil: a case report and literature review suggesting ethnic predisposition ［J］．J Clin Pharm Ther, 2013, 38(4): 321-6. DOI: 10.1111/jcpt.12050[2] Servais A, Lechat P, Zahr N, et al. [Tubular transporters OAT1 and MRP2 and clearance of adefovir] ［J］．Nephrol Ther, 2005, 1(5): 296-300. DOI：10.1016/ j.nephro.2005.06.011[3] Vigan&amp;ograve; M, Lampertico P, Colombo M. Drug safety evaluation of adefovir in HBV infection ［J］．Expert Opin Drug Saf, 2011, 10(5): 809-18. DOI：10.1517/14740338.2011.593507[4] Kim du H, Sung D H, Min Y K. Hypophosphatemic osteomalacia induced by low-dose adefovir therapy: focus on manifestations in the skeletal system and literature review ［J］．J Bone Miner Metab, 2013, 31(2): 240-6. DOI：10.1007/s00774-012-0384-y[5] Lin Y, Pan F, Wang Y, et al. Adefovir dipivoxil-induced Fanconi syndrome and its predictive factors: A study of 28 cases ［J］．Oncol Lett, 2017, 13(1): 307-14. DOI：10.3892/ol.2016.5393[6] Minemura M, Tokimitsu Y, Tajiri K, et al. Development of osteomalacia in a post-liver transplant patient receiving adefovir dipivoxil ［J］．World J Hepatol, 2010, 2(12):442-6. DOI：10.4254/wjh.v2.i12.442[7] Fabbriciani G, de Socio G V, Massarotti M, et al. Adefovir induced hypophosphatemic osteomalacia ［J］．Scand J Infect Dis, 2011, 43(11-12): 990-2. DOI：10.4254/wjh.v2.i12.442[8] Lin J, Zhuo Y, Zhang D. Nephrolithiasis and Osteomalacia associated with adefovir-induced Fanconi syndrome in a patient with hepatitis B ［J］．BMC Nephrol, 2017,18(1): 275.DOI：10.1186/s12882-017-0693-4[9] Qian Y Y, Dai Z J, Ruan L Y, et al. Low-dose adefovir dipivoxil-induced hypophosphatemia osteomalacia in five chronic hepatitis B virus-infected patients. Is low-dose adefovir dipivoxil-induced nephrotoxicity completely reversible? ［J］．Drug Des Devel Ther, 2019, 13: 1127-33.DOI：10.2147/DDDT.S192632[10] Jia H Y, Ding F, Chen J Y, et al. Early kidney injury during long-term adefovir dipivoxil therapy for chronic hepatitis B ［J］．World J Gastroenterol, 2015, 21(12):3657-62.DOI：10.3748/wjg.v21.i12.3657</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
