<?xml version="1.1" encoding="utf-8"?>
<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">MRP</journal-id><journal-title-group><journal-title>Medical Research and Practice</journal-title></journal-title-group><issn>2993-9690</issn><eissn>2993-9704</eissn><publisher><publisher-name>Art and Technology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/MRP.7570</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>华法林抗凝作用的药学监护</title><url>https://artdesignp.com/journal/MRP/2/7/10.61369/MRP.7570</url><author>张玥,徐海燕,张鹤</author><pub-date pub-type="publication-year"><year>2024</year></pub-date><volume>2</volume><issue>7</issue><history><date date-type="pub"><published-time>2024-07-20</published-time></date></history><abstract>华法林为香豆素类抗凝药，通过抑制维生素K依赖的凝血因子发挥抗凝作用，许多药物和食物可影响华法林的抗凝作用，导致用量不足或出血。临床医生、护士以及临床药师在使用华法林时要特别注意。因此，华法林的抗凝机制是什么？华法林的抗凝目标是什么？华法林导致凝血功能增加的原因分析？因此，在服用华法林期间不得自己擅自加用或停用药物，应有专业人士指导用药越来越受到人们的关注。本文介绍一例因药物相互作用致华法林凝血作用增强的药学监护，供大家学习交流。</abstract><keywords>药物相互作用,华法林,药学监护</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>[1] 朱剑萍，赵蕊 . 华法林药效的影响因素［J］．临床药物治疗杂志 ,2009, 7(3):55-58.[2] Bonow RO, Carabello BA, Chatterjee K, et al. 2008 focused updated incorporated into the ACC/AHA 2006guidelines for the management of patients with valvularheart diseases［J］．2008, 52(13): 141-2.[3] 王 斌 徐志云 叶小飞．华人心脏机械瓣膜置换术后华法林抗凝强度标准的系统评价［J］．国际心血管病杂志，2010,37(06):361-366.[4] 张瑜，游鹏程，郑秋山．115 例华法林临床应用调查分析［J］．中国药物警戒，2011，8 （9）: 524-527.[5] 孙云川 王 昕 秦明照 等．药物相互作用致心房颤动患者 INR 异常升高的病例分析及文献复习［J］．临床药物治疗杂志 2013,11(03):48-50.[6] Marusic S, Gojo-Tomic, Bacic-Vrca V, et al. Enhancedanticoagulant effect of warfarin in a patient treated withcloxacillin［J］．2012, 50(6): 431-3.[7] 中华医学会心血管病学分会 中国老年学学会心脑血管病专业委员会．华法林抗凝治疗的中国专家共识［J］．中华内科杂志 2013,11(03):48-50.[8] Teichert M, Van Noord C, Uitterlinden AG, et al.Proton pump inhibitors and the risk of overanticoagulation during acenocoumarol maintenance treatment［J］．Br J Haematol, 2011, 153(3): 379-85.[9] Li XQ, Andersson TB, Ahlstr 觟m M, et al. Comparisonof inhibitory effects of the proton pump -inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450activities［J］．Drug Metab Dispos, 2004, 32(8): 821-7.[10] McCarthy DM, McLaughlin T, Yazdani C, et al. Effects of co-therapy with early proton pump inhibitors(PPIs) on the occurrence of side effects of other drugswith potential for interaction with PPIs: a cohort study［C］．USA: WB SAUNDERS CO, 2002: A210-A210.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
