<?xml version="1.1" encoding="utf-8"?>
<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">MRP</journal-id><journal-title-group><journal-title>Medical Research and Practice</journal-title></journal-title-group><issn>2993-9690</issn><eissn>2993-9704</eissn><publisher><publisher-name>Art and Technology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/MRP.2026090042</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>circRNA-miRNA-mRNA 网络解析AVF血管重塑机制</title><url>https://artdesignp.com/journal/MRP/4/9/10.61369/MRP.2026090042</url><author>赵明,陈水玲,李万军,年瑞,陈伟,宏朝路</author><pub-date pub-type="publication-year"><year>2026</year></pub-date><volume>4</volume><issue>9</issue><history><date date-type="pub"><published-time>2026-09-20</published-time></date></history><abstract>自体动静脉内瘘（Arteriovenous Fistula,AVF）狭窄与转录后调控驱动的血管重构密切相关。测序共筛得211个差异miRNA 和866个差异circRNA。ceRNA 分析提示，miR-665/miR-296轴可能通过调控CREB3L1和RXFP1，促进平滑肌细胞增殖及炎症、纤维化反应，参与内瘘失功进程。该轴有望作为AVF 狭窄的潜在预警与干预靶点。</abstract><keywords>自体动静脉内瘘,血管生成,全转录组学</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>[1]Khajedaluee M,Ahmadi Ghezeldasht S,Mosavat A,et al.Prevalence and risk factors of chronic kidney disease in a populated area with highly moving populations[J/OL].medRxiv,2020.[2] 陈立洲, 姚立正, 李文会, 等. 自体动静脉内瘘阻塞介入治疗疗效和术后通畅率影响因素分析[J]. 医学影像学杂志,2022,32(3):500-504.[3] 沈凤, 陶晓静, 欧和生等.miRNA-145对血管平滑肌细胞功能调节与心血管疾病研究进展[J]. 生理科学进展,2017(05):357-361.[4]Greene J,Baird AM,Brady L,Lim M,et al.Circular RNAs:biogenesis, function and role in human diseases[J].Front Mol Biosci.2017;4:38.[5] 廖露, 邹丽婷, 付梦茹, 等. 血清代谢组学与维持性血液透析患者自体动静脉内瘘狭窄的关系[J]. 中国血液净化,2023,22(03):206-209.[6] 魏思琪, 孔德阳. 动静脉内瘘成熟障碍机制研究进展[J]. 肾脏病与透析肾移植杂志,2021,30(04):384-388.[7] 叶祖扬, 邹迪莎, 潘罅. 自体动静脉内瘘手术前后血管组织病理改变的研究进展[J]. 临床肾脏病杂志,2019,19(08):633-636.[8] 叶才博, 陈祥宇, 杜杰勇, 等. 基于miR-665/DRAM1信号介导的自噬探讨补阳还五汤延缓血管衰老的作用[J]. 南京中医药大学学报,2024,40(04):369-378.[9]Yingying H,Xiaoxiao D,Xiangliu C,et al.MiR-301a-5p/SCIN promotes gastric cancer progression via regulating STAT3 and NF-&amp;kappa;B signaling.[J].Journal of Cancer,2021,12(18):5394-5403.[10]Zhiqin L,Yang L,Jingya Y,et al.Circular RNA hsacirc0056836 functions an oncogenic gene in hepatocellular carcinoma through modulating miR-766-3p/FOSL2 axis.[J].Aging,2020,12(3):2485-2497.[11]Yanfeng J,Xinyan S,Xuankai S,et al.Up-regulation of collagen type V alpha 2(COL5A2) promotes malignant phenotypes in gastric cancer cell via inducing epithelial&amp;ndash;mesenchymal transition (EMT)[J].Open Medicine,2023,18(1):20220593.[12]Giorgio D C,Morretta E,Lupia A,et al.Bile acids serve as endogenous antagonists of the Leukemia inhibitory factor(LIF)receptor in oncogenesis.[J].Biochemicalpharmacology,2024,223:116134.[13]Katarzyna A,Anita H,Renata T,et al.MMP9:A Tough Target for Targeted Therapy for Cancer[J].Cancers,2022,14(7):1847-1847.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
