MRPMedical Research and Practice2993-96902993-9704Art and Technology10.61369/MRP.2026090029Article睡眠剥夺与高果糖饮食诱导MAFLD 机制的研究进展及其协同作用https://artdesignp.com/journal/MRP/4/9/10.61369/MRP.2026090029陆妍,宋吉涛2026492026-09-20代谢相关脂肪性肝病（MAFLD）已成为全球公共卫生的严峻挑战。现代生活方式中，睡眠稳态破坏与高果糖饮食伴随出现，二者存在潜在的非线性协同致病作用。本文系统综述了这两种环境应激在脂质从头合成、胰岛素信号传导及肠道微环境稳态中的交互作用机制，重点阐述“肠道氧化应激累积- 屏障功能崩溃- 菌群代谢物易位”这一轴线在连接环境压力与系统性炎症中的核心地位，并基于“生物钟- 代谢耦合”理论，探讨恢复昼夜节律与调整饮食习惯的联合干预策略。睡眠剥夺,高果糖饮食,MAFLD,肠道- 肝脏轴,胰岛素抵抗,氧化应激

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