<?xml version="1.1" encoding="utf-8"?>
<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">MRP</journal-id><journal-title-group><journal-title>Medical Research and Practice</journal-title></journal-title-group><issn>2993-9690</issn><eissn>2993-9704</eissn><publisher><publisher-name>Art and Technology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/MRP.2026090023</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>中医药调控神经元稳态治疗老年失眠研究进展</title><url>https://artdesignp.com/journal/MRP/4/9/10.61369/MRP.2026090023</url><author>唐文佳,黄刚,王越,梁政亭,梁瑞宁</author><pub-date pub-type="publication-year"><year>2026</year></pub-date><volume>4</volume><issue>9</issue><history><date date-type="pub"><published-time>2026-09-20</published-time></date></history><abstract>老年失眠发病率高且机制复杂，与HIF-1信号通路活性异常及神经稳态失衡有关，以往的治疗效果有限。有研究显示，补肾安志方为老年性失眠提供了多靶点干预新策略，可为中医药现代化治疗老年失眠的理论创新与药物研发提供科学依据。本文整合了神经自噬、端粒耗损等多维度机制，阐释补肾安志方补肾填精、安神定志的药理依据，并提出补肾安志方可通过靶向结合AKT1负反馈调节HIF-1通路，纠正脑内异常代谢与神经炎症，恢复中枢神经系统(Central Nervous System，CNS) 的状态，为改善&amp;ldquo;肾虚为本&amp;rdquo;病机的老年性失眠提供诊疗思路。</abstract><keywords>补肾安志方,HIF-1信号通路,衰老性失眠,神经元稳态</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>[1] 失眠症诊断和治疗指南(2025 版)[J]. 中国睡眠研究会. 中华医学杂志,2025(34).[2]Xia L, Liu H, Ren J. A revi ew of symptom, pathogenesis and treatment characteri stics of the elderly with chronic insomnia[J].Medicine,2025,104(5):e41346.Copyright &amp;copy; This Work is Licensed under A Commons Attribution-Non Commercial 4.0 International License. | 129[3]Madan Jha V. The prevalence o f sleep loss and sleep disorders in young and old adults. Aging Brain. 2022;3:100057.[4] 马瑞红, 王雪可, 崔应麟. 老年失眠症的中医研究进展[J]. 中国中医药现代远程教育,2023,21(22):200-202.[5] 孙洁, 郝振华, 张星平, 等. &amp;ldquo;补肾安志方&amp;rdquo;治疗以&amp;ldquo;夜寐早寤&amp;rdquo;为主症的老年不寐临床研究[J]. 中医药学报,2022,50(07):65-68.[6] 郝振华, 孙洁, 魏璞, 等. 补肾安志方治疗老年性失眠临床观察[J]. 实用中医药杂志,2018,34(01):39-40.[7] 任小娟, 陈小兵, 王冠英, 等.D- 半乳糖联合对氯苯丙氨酸致肾不藏志不寐大鼠肾脏氧化应激和炎性因子的实验研究[J]. 新疆中医药,2021,39(04):9-12.[8] 何厅, 翁月, 黄瑾. 缺氧诱导因子的调控机制及其在疾病治疗中的药物开发进展[J/OL]. 中南药学,2626,5(1)1-8.[9] 刘婷婷, 白忠宏, 段宏伟, 等. 褪黑素通过AKT1/HIF-1&amp;alpha; 信号通路促进奶牛子宫内膜上皮细胞损伤修复[J/OL]. 畜牧兽医学报,2026,5(1)1-18.[10]Xie Y, Shi X, Sheng K, et al. PI3K/ Akt signaling transduction pathway, erythropoiesis and glycolysis in hypoxia (Review). Mol Med Rep. 2019;19(2):783-791.[11]IoannaMaria G, Eleni K, Kalliopi P. Calcitriol Suppresses HIF-1 and HIF-2 Transcriptional Activity by Reducing HIF-1/2&amp;alpha; Protein Levels via a VDR-IndependentMechanism[J]. Cells,2020,9(11):2440-2440.[12]Ke XJ, Zhang JJ. Changes in HIF-1&amp;alpha;, VEGF, NGF and BDNF levels in cerebrospinal fluid and their relationship with cognitive impairment in patients with cerebralinfarction. J Huazhong Univ Sci Technolog Med Sci. 2013;33(3):433-437.[13]Huang H, Ni K, Li C. TRIM25 promotes glioblastoma progression by stabilizing HIF-1&amp;alpha; expression in normoxia through K11/K29 polyubiquitination. Cell DeathDis. 2026;17(1):530.[14]Tang L, Yang YQ, Cheng FH. Rhodiolae Crenulatae Radix et Rhizoma protects brain microvascular endothelial cells from ischemia and hypoxia injury by regulatingPI3K/AKT/GSK3&amp;beta; pathway[J]. Zhongguo Zhong yao za zhi,2025,50(11):3127-3136.[15]Yang C, Wang X, Ye X. Spati otemporal Immune Dynamics in Experimental Retinal Ganglion Cell Injury Models. Immun Inflamm Dis. 2025;13(10):e70284.[16]Zhang J, Li J, Li Y. cGAS-ST ING axis: A central regulator of neural homeostasis and neuroinflammatory pathogenesis. Neural Regen Res. 2026;21(8):3285-3300.[17]Wu Y, Li Z, Di ng T. Bidirectional regulation of neuronal autophagy in ischemic stroke: Mechanisms and therapeutic potential. Ageing Res Rev. 2025;111:102842.[18]Feng X, Ma W, Zhu J. Dexmedetomidine alleviates early brain injury following traumatic brain injury by inhibiting autophagy and neuroinflammation through theROS/Nrf2 signaling pathway. Mol Med Rep. 2021;24(3):661.[19] 罗明, 王孟阳, 张修民, 等. 苦参碱调节AMPK/mTOR/ULK1 信号通路对创伤性脑损伤大鼠神经元自噬的影响[J]. 广州中医药大学学报,2026,43(2):449-455.[20] 陈仁智, 谭霞, 周琼, 等.LncRNA 调控的神经元自噬在阿尔茨海默病发生发展机制中作用的研究进展[J]. 医药前沿,2025,15(18):30-33.[21]Baylie T, Gugsa E, Jemal M . Telomerase and chronic inflammation as central molecular links in aging. Biomed Pharmacother. 2026;196:119104.[22]Xu F. The Aging Mechanism and the Telomere Depleti on Theory[J].Academic Journal of Science and Technology,2025,18(1):676-680.[23]Eşel G, Mermer BD, Eker O&amp;Ouml;. Telomere length in sleep disorders[J].Experimental gerontology,2025,209112851.[24]Tempaku FP, D&amp;rsquo;Almeida V, Andersen LM. Sleep is associated with telomere shortening: A population-based longitudinal study[J].Journal of sleep research,2024,34(1):e14274.[25]Dan H, Peilin M, Chun&amp;rsquo;e L. Association between telomere length and insomnia: A mendelian randomization and colocalization study[J].Sleep Medicine,2022,100304-310.[26]EJC, Stephanie E, Alyssa G. Insomni a and Telomere Length in Older Adults.[J].Sleep,2016,39(3):559-64.[27]L&amp;oacute;pez-Ot&amp;iacute;n C, Blasco MA, Partridge L. Hallmarks of aging: An expanding universe. Cell. 2023;186(2):243-278.[28] 张钰纯. 中老年人群睡眠行为与端粒长度的关联性研究[D]. 南方医科大学,2024.[29] 冀绪政, 张彪. 老年失眠的中医治疗现状研究[J]. 中国医学创新,2026,23(08):164-168.[30] 靳亚荣, 张星平, 王凯凯, 等. 补肾安志方联合认知行为疗法治疗肾不藏志型失眠症临床观察[J]. 中医药学报,2022,50(01):61-64.[31]Qing L, Zhenting W, Xiaohua Z. miR-485-5p/HSP90 axis blocks Akt1 phosphorylation to suppress osteosarcoma cell proliferation and migration via PI3K/AKTpathway[J]. Journal of physiology and biochemistry,2020,76(2):279-290.[32] 任小娟, 王晶, 陈小兵, 等. 远志对肾不藏志不寐大鼠睡眠影响的实验研究[J]. 新疆医科大学学报,2022,45(07):770-775.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
