TRPV1、TRPA1 及TRPM8 在疼痛中的作用机制及研究进展

MRP

Medical Research and Practice

2993-96902993-9704

Art and Technology

10.61369/MRP.2026060025

Article

TRPV1、TRPA1 及TRPM8 在疼痛中的作用机制及研究进展https://artdesignp.com/journal/MRP/4/6/10.61369/MRP.2026060025莫洁红,赵雷

2026

2026-06-20

瞬时受体电位（TRP）通道是参与健康及疼痛、炎症、代谢紊乱等疾病过程的多功能信号分子。其中，TRPA1 和TRPM8 感知冷觉温度，而 TRPV1 感知热觉温度，三者均对温度伤害感受及神经病理性疼痛至关重要。阿片类镇痛药疗效有限，且会导致严重的依赖性和成瘾性。因此，研究 TRP 通道可为开发新型非成瘾性镇痛靶点提供新思路。本综述总结了与疼痛相关的关键 TRP 通道（TRPV1、TRPA1、TRPM8）的研究现状、致痛机制及抑制剂研究进展，阐述了其生物学特性及在不同疼痛类型中的作用，并对其作为非成瘾性镇痛靶点的临床转化前景进行了展望。TRP 离子通道,疼痛,镇痛分子靶点

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