MRPMedical Research and Practice2993-96902993-9704Art and Technology10.61369/MRP.2026050040Article茉莉酸类化合物对炎症信号通路的调控及其抗炎机制研究进展https://artdesignp.com/journal/MRP/4/5/10.61369/MRP.2026050040张东风,贺拥军,舒逸青,丁子银2026452026-05-20茉莉酸（JA）与茉莉酸甲酯（MeJA）作为植物内源关键脂质信号分子，其化学结构和动物体内具有抗炎活性的前列腺素存在高度结构同源性，现已成为抗炎药理领域的研究热点。大量研究证实，茉莉酸类化合物不仅能够有效抑制各类促炎细胞因子释放，还可通过多靶点干预胞内信号转导网络，发挥多层次抗炎调控效应。本文系统梳理茉莉酸类物质对 NF-κB、MAPK、NLRP3 炎症小体及 Nrf2/HO-1 等经典炎症相关信号通路的调控规律，归纳其在神经炎症、类风湿关节炎、溃疡性结肠炎、急性肺损伤等炎症相关疾病模型中的最新研究成果，以期为该类天然活性成分的新药研发与临床转化提供理论支撑。茉莉酸,茉莉酸甲酯,NF-κB,MAPK,NLRP3 炎症小体,Nrf2,抗炎分子机制

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