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<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">MRP</journal-id><journal-title-group><journal-title>Medical Research and Practice</journal-title></journal-title-group><issn>2993-9690</issn><eissn>2993-9704</eissn><publisher><publisher-name>Art and Technology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/MRP.2026050011</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>手性药物合成中立体化学问题的解决策略研究</title><url>https://artdesignp.com/journal/MRP/4/5/10.61369/MRP.2026050011</url><author>潘嘉路</author><pub-date pub-type="publication-year"><year>2026</year></pub-date><volume>4</volume><issue>5</issue><history><date date-type="pub"><published-time>2026-05-20</published-time></date></history><abstract>手性特征，是左手与右手的关系，可以镜面重合但无法在空间上完全重叠。手性药物的药效、毒性和代谢特性在很大程度上取决于其立体构型，因此精准控制手性中心的生成和立体选择性是实现高效药物合成的核心。在探索不对称有机合成的历程中，已有数位科学家因对手性催化的重要贡献摘得诺贝尔化学奖桂冠。本文聚焦手性药物合成中的立体化学问题，结合其研究在药学领域的实际运用案例，旨在为手性药物合成提供理论指导和实践参考，提高手性药物的合成效率和质量控制水平，为新型手性药物的研发提供有力支持。</abstract><keywords>手性药物,立体化学,不对称催化合成</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>[1] 李晓红，李灿。多相不对称催化氢化研究进展[J]。化学进展，2003,15(3) :204-214[2]Ana R. Rodriguez, Bernd W. Spur.First total synthesis of the anti-inflammatory lipid mediator Resolvin D6. Tetrahedron Letters 53 (2012): 86&amp;ndash;89.[3]Bo Song, Yue Ji, Shu-Bo Hu, Chang-Bin Yu, Yong-Gui Zhou.Synthesis of chiral c-sultams through intramolecular reductive amination with sulfonylcarbamate as N-source. Tetrahedron Letters 58 (2017) 1528&amp;ndash;1530[4]Dominika Krisˇtofkov ,Vikt ria Modrock ,Mria Mec ˇiarov , and Radovan S ˇebesta. Green Asymmetric Organocatalysis. ChemSusChem 2020, 13,2828&amp;ndash;2858[5]Xiang SH, Tan B. Advances in asymmetric organocatalysis over the last 10 years. Nat Commun. 2020 Jul 29;11(1):3786.[6]Seayad J, List B. Asymmetric organocatalysis. Org Biomol Chem. 2005 Mar 7;3(5):719-24.[7]Benjamin List, Richard A. Lerner, Carlos F. Barbas Ⅲ . Proline-Catalyzed Direct Asymmetric Aldol Reactions. J Am Chem. Soc. 2000, 122, 2395-2396.[8]Kateri A. Ahrendt, Christopher J. Borths, David W. C. MacMillan.New Strategies for Organic Catalysis: The First Highly Enantioselective Organocatalytic Diels&amp;minus;Alder Reaction. J Am Chem Soc,2000, 122, 4243-4244.[9]Jang HY, Hong JB, MacMillan DW. Enantioselective organocatalytic singly occupied molecular orbital activation: the enantioselective alpha-enolation of aldehydes. J Am Chem Soc. 2007 Jun 6;129(22):7004-5.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
