龙血素A 对JAK2/STAT3信号通路减轻MIRI的机制研究

MRP

Medical Research and Practice

2993-96902993-9704

Art and Technology

10.61369/MRP.2026050009

Article

龙血素A 对JAK2/STAT3信号通路减轻MIRI的机制研究https://artdesignp.com/journal/MRP/4/5/10.61369/MRP.2026050009魏成磊,黄照河

2026

2026-05-20

心血管疾病已成为严重威胁人类健康的重大公共卫生问题，心肌梗死致死率居高不下。临床血运重建虽能挽救缺血心肌，但可引发心肌缺血再灌注损伤（MIRI），其机制与活性氧大量生成、细胞凋亡异常及炎症反应密切相关，最终可导致心功能下降甚至心力衰竭。目前MIRI的临床干预效果有限，机制尚未完全阐明，亟需探索新的治疗靶点。JAK2/STAT3信号通路在MIRI中具有重要心肌保护作用，可通过抑制氧化应激、凋亡与炎症发挥心脏保护效应。研究表明，龙血素能够调控该通路减轻心肌损伤，而龙血素A作为龙血竭的主要活性成分，其通过JAK2/STAT3通路干预MIRI 的具体机制仍有待系统阐明。本文就相关研究进行综述，旨在为心肌缺血再灌注损伤的防治提供理论依据，推动中医药在心血管疾病中的应用与发展。心肌缺血再灌注损伤,JAK2/STAT3信号通路,龙血素A

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