<?xml version="1.1" encoding="utf-8"?>
<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">MRP</journal-id><journal-title-group><journal-title>Medical Research and Practice</journal-title></journal-title-group><issn>2993-9690</issn><eissn>2993-9704</eissn><publisher><publisher-name>Art and Technology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/MRP.2026050007</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>IgG4相关疾病：一例累颞骨的IgG4相关炎性假瘤病例报道</title><url>https://artdesignp.com/journal/MRP/4/5/10.61369/MRP.2026050007</url><author>王珂欣,龚桃根</author><pub-date pub-type="publication-year"><year>2026</year></pub-date><volume>4</volume><issue>5</issue><history><date date-type="pub"><published-time>2026-05-20</published-time></date></history><abstract>IgG4 相关性疾病（IgG4-Related Disease）是一种慢性免疫介导的多器官纤维性炎症性疾病，常见于胰腺、唾液腺、泪腺等部位。本文目的通过一例以耳鼻表现为主的IgG-RD，并归纳阅读文献中获得的16例相关病例，进行文献综述，总结IgG4-RD的流行病学表现、临床表现、诊断标准及治疗方案。使在临床上能快速诊断出IgG4-RD，避免延误治疗。</abstract><keywords>IgG4相关性疾病,颞骨炎性假瘤,诊断,治疗</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>[1]Avincsal, M.O. and Y. Zen, The Histopathology of IgG4-Related Disease. Curr Top Microbiol Immunol, 2017. 401: p. 45-60.[2] 尚丽婧, 李芳瑜, 崔舜, IgG4 相关性疾病的研究进展[J].疑难病杂志, 2022. 21(04): p. 436-440.[3] 卜春艳, 等. 累及鼻腔鼻窦IgG4 相关性疾病的研究进展[J].临床耳鼻咽喉头颈外科杂志, 2021. 35(11): p. 1042-1047.[4]Kawabata, H., et al., IgG4-related Autoimmune Hepatitis with a Suspected Drug-induced Etiology. Intern Med, 2020. 59(11): p. 1401-1405.[5]Taguchi, T., et al., Surgical Treatment for Giant Multiple Coronary Artery Aneurysms Caused by an IgG4-Related Disease. Cureus, 2024. 16(5): p. e60115.[6]Schiffenbauer, A.I., et al., IgG4-related disease presenting as recurrent mastoiditis. The Laryngoscope, 2012.
[7]Li, L., et al., IgG4-Related Disease of Bilateral Temporal Bones. Annals of Otology, Rhinology &amp;amp; Laryngology, 2016.[8]Bittencourt, A.G., et al., IgG4-related sclerosing disease of the temporal bone. Otol Neurotol, 2013. 34(3): p. e20-1.[9]Vuncannon, J.R., et al., Diagnostic Challenges in a Case of IgG4-RD Affecting the Temporal Bone. Ann Otol Rhinol Laryngol, 2017. 126(3): p. 241-244.[10]Barnado, A.L. and M.A. Cunningham, IgG4-Related Disease Presenting as Recurrent Mastoiditis With Central Nervous System Involvement. J Investig Med High Impact Case Rep, 2014. 2(3).[11]Chowsilpa, S., et al., Temporal bone involvement of IgG4-related disease: a rare condition misleading to petrous apicitis causing lateral rectus palsy. BMJ Case Rep, 2019.12(2).[12]Cho, H.K., et al., Otologic Manifestation in IgG4-Related Systemic Disease. Clin Exp Otorhinolaryngol, 2011. 4(1): p. 52-4.[13]Ren, Q., et al., Otological IgG4-Related Disease With Inner Ear Involvement: A Case Report and Review of Literature. Ear Nose Throat J, 2022. 101(10): p. Np441-np444.[14]Wuesthoff, C., A. Allende, and N. Patel, IgG4 disease of the ear: Report and review. SAGE Open Med Case Rep, 2018. 6: p. 2050313x18791428.[15]Masterson, L., et al., Immunoglobulin G4 related systemic sclerosing disease involving the temporal bone. J Laryngol Otol, 2010. 124(10): p. 1106-10.[16]Wick, C.C., et al., IgG4-related disease causing facial nerve and optic nerve palsies: Case report and literature review. Am J Otolaryngol, 2016. 37(6): p. 567-571.[17]Deshpande, V., et al., Recurrent Mastoiditis Mimics IgG4 Related Disease: A Potential Diagnostic Pitfall. Head Neck Pathol, 2016. 10(3): p. 314-20.[18] 胡明, 王玮, 程岩, 以耳部病变为首发症状的IgG4 相关硬化性疾病一例[J].中华耳鼻咽喉头颈外科杂志, 2018. 53(02): p. 140-143.[19]Cheng, X., Y. Shu, and B. Chen, A solely ear-involved IgG4-related sclerosing disease with two-years following-up. Eur Ann Otorhinolaryngol Head Neck Dis, 2019. 136(5): p. 401-403.[20] 周海飞, et al., IgG4 相关疾病的影像学特征分析[J].中国CT和MRI 杂志, 2023. 21(04): p. 168-170.[21]Deshpande, V., et al., Consensus statement on the pathology of IgG4-related disease. Mod Pathol, 2012. 25(9): p. 1181-92.[22]Umehara, H., et al., The 2020 revised comprehensive diagnostic (RCD) criteria for IgG4-RD. Mod Rheumatol, 2021. 31(3): p. 529-533.[23]Cabrera Villegas, A., et al., Inflammatory pseudotumour of the infratemporal fossa visualized with (18)F-FDG PET/CT. Rev Esp Med Nucl Imagen Mol, 2017. 36(6): p. 392-395.[24]Martinez, L.L., et al., Abundance of IgG4+ plasma cells in isolated reactive lymphadenopathy is no indication of IgG4-related disease. Am J Clin Pathol, 2014. 142(4): p. 459-66.[25]Vasaitis, L., IgG4-related disease: A relatively new concept for clinicians. Eur J Intern Med, 2016. 27: p. 1-9.[26]Hamano, H., et al., IgG4-related Disease - A Systemic Disease that Deserves Attention Regardless of One&amp;rsquo;s Subspecialty. Intern Med, 2018. 57(9): p. 1201-1207.[27]Khosroshahi, A., et al., International Consensus Guidance Statement on the Management and Treatment of IgG4-Related Disease. Arthritis Rheumatol, 2015. 67(7): p. 1688-99.[28]Omar, D., et al., Glucocorticoids and steroid sparing medications monotherapies or in combination for IgG4-RD: a systematic review and network meta-analysis. Rheumatology (Oxford), 2020. 59(4): p. 718-726.[29] 江新华, 毛卫, 黄义华, 免疫球蛋白G4相关性疾病累及多脏器1 例病例报道[J].当代医学, 2022. 28(16): p. 104-107.[30]&amp;Uuml;nl&amp;uuml;, S., et al., Exploring the depths of IgG4: insights into autoimmunity and novel treatments. Front Immunol, 2024. 15: p. 1346671.[31]Lanzillotta, M., et al., Fibrotic phenotype of IgG4-related disease. Lancet Rheumatol, 2024. 6(7): p. e469-e480.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
