<?xml version="1.1" encoding="utf-8"?>
<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">MRP</journal-id><journal-title-group><journal-title>Medical Research and Practice</journal-title></journal-title-group><issn>2993-9690</issn><eissn>2993-9704</eissn><publisher><publisher-name>Art and Technology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/MRP.12739</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>艾叶的多重药理活性及其临床应用研究进展</title><url>https://artdesignp.com/journal/MRP/3/2/10.61369/MRP.12739</url><author>汤达,顾任钧,王玺,韩暄</author><pub-date pub-type="publication-year"><year>2025</year></pub-date><volume>3</volume><issue>2</issue><history><date date-type="pub"><published-time>2025-02-20</published-time></date></history><abstract>艾叶（Artemisia argyi L&amp;eacute;vl.et Vant.）是一种具有多种药理活性和生物活性的植物药，主要成分包括黄酮类、酚酸类和萜类化合物，具有抗炎、抗菌和免疫调节等作用。常用于治疗皮炎、心血管疾病及妇科疾病，同时被誉为&amp;ldquo;妇科圣药&amp;rdquo;。其抗炎作用通过抑制MAPK/PI3K-AKT信号通路实现，显著减少炎症反应。近年来，艾叶在慢性疾病和肿瘤治疗中的应用前景广阔，未来研究应重点关注其提取技术优化及临床联合用药的安全性。</abstract><keywords>艾叶,药理活性,抗炎,提取技术,临床应用</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>[1]HAN X, SONG Y, HUANG R, et al. Anti-Inflammatory and Gut Microbiota Modulation Potentials of Flavonoids Extracted from Passiflora foetida Fruits [J]. Foods (Basel,Switzerland), 2023, 12(15).[2]DUAN L, ZHANG C, ZHANG C, et al. Green Extraction of Phenolic Acids from Artemisia argyi Leaves by Tailor-Made Ternary Deep Eutectic Solvents [J]. Molecules (Basel,Switzerland), 2019, 24(15).[3]CHEN L, ZHU Y, WANG Y, et al. The water-soluble subfraction from Artemisia argyi alleviates LPS-induced inflammatory responses via multiple pathways and targets invitro and in vivo [J]. Journal of ethnopharmacology, 2024, 319(Pt 3): 117364.[4]WANG H, ZHANG Y, YU D, et al. A review of the research progress on Artemisia argyi Folium: botany, phytochemistry, pharmacological activities, and clinicalapplication [J]. Naunyn-Schmiedeberg's archives of pharmacology, 2024.[5]ZHANG Z, FU X, WANG Y, et al. In vivo anti-hepatitis B activity of Artemisia argyi essential oil-loaded nanostructured lipid carriers. Study of its mechanism of action bynetwork pharmacology and molecular docking [J]. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2023, 116: 154848.[6]ZENG K W, WANG S, DONG X, et al. Sesquiterpene dimer (DSF-52) from Artemisia argyi inhibits microglia-mediated neuroinflammation via suppression of NF-&amp;kappa;B,JNK/p38 MAPKs and Jak2/Stat3 signaling pathways [J]. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2014, 21(3): 298-306.[7]WANG H, ZHANG M, MA Y, et al. Selective inactivation of Gram-negative bacteria by carbon dots derived from natural biomass: Artemisia argyi leaves [J]. Journal ofmaterials chemistry B, 2020, 8(13): 2666-72.[8]SHI X S, SONG Y P, MENG L H, et al. Isolation and Characterization of Antibacterial Carotane Sesquiterpenes from Artemisia argyi Associated Endophytic Trichodermavirens QA-8 [J]. Antibiotics (Basel, Switzerland), 2021, 10(2).[9]LIU P, ZHONG L, XIAO J, et al. Ethanol extract from Artemisia argyi leaves inhibits HSV-1 infection by destroying the viral envelope [J]. Virology journal, 2023, 20(1): 8.[10]XUE G M, ZHU D R, HAN C, et al. Artemisianins A-D, new stereoisomers of seco-guaianolide involved heterodimeric [4+2] adducts from Artemisia argyi induceapoptosis via enhancement of endoplasmic reticulum stress [J]. Bioorganic chemistry, 2019, 84: 295-301.[11]D&amp;uuml;RR L, REINHARDT J K, DOBRZYŃSKI M, et al. A Dimerosesquiterpene and Sesquiterpene Lactones from Artemisia argyi Inhibiting Oncogenic PI3K/AKT Signalingin Melanoma Cells [J]. Journal of natural products, 2022, 85(11): 2557-69.[12] 李素芬, 黄燕. 滋肾育胎丸联合优思明对PCOS 不孕症患者子宫内膜容受性、内分泌指标及妊娠结局的影响 [J]. 贵州医科大学学报, 2024, 49(01): 151-6.[13]WU Z X, CAI M J, HUANG P D, et al. Comparative efficacy and dysmenorrhea score of 6 object-separated moxibustions for the treatment of Chinese patients withdysmenorrhea: A systematic review and network meta-analysis [J]. Medicine, 2021, 100(26): e26185.[14]YUAN Q L, GUO T M, LIU L, et al. Traditional Chinese medicine for neck pain and low back pain: a systematic review and meta-analysis [J]. PloS one, 2015, 10(2):e0117146.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
