慢性疼痛合并认知异常的研究进展

MRP

Medical Research and Practice

2993-96902993-9704

Art and Technology

10.61369/MRP.11889

Article

慢性疼痛合并认知异常的研究进展https://artdesignp.com/journal/MRP/2/12/10.61369/MRP.11889韦谭利,王哲银

2024

212

2024-12-20

慢性疼痛（CP）是一种持续超过正常愈合时间的疼痛综合征，其与认知异常的共病现象严重损害患者生活质量及社会功能。研究表明，约半数慢性疼痛患者伴随注意力下降、记忆减退等认知障碍，其机制涉及大脑结构重塑（如前额叶皮质、海马灰质萎缩）、神经炎症（促炎因子如IL-6、TNF-α介导突触损伤）及神经递质失衡（GABA能抑制减弱、LC-NE系统功能障碍）。评估方法包括主观量表（如MoCA）、生物标志物（炎症因子水平）和神经影像技术（fMRI、脑电图），但客观定量指标仍待开发。因此，本文旨在总结慢性疼痛合并认知障碍的最新进展，为相关研究者以及临床医师提供系统认识，也为未来研究应聚焦神经环路机制与生物标志物开发提供思路，为临床诊疗提供精准依据。慢性疼痛,认知异常,神经炎症反应,静息脑电图 ,MoCA量表

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