非啮齿类骨肉瘤动物模型的构建及AI在其的应用

MRP

Medical Research and Practice

2993-96902993-9704

Art and Technology

10.61369/MRP.11880

Article

非啮齿类骨肉瘤动物模型的构建及AI在其的应用https://artdesignp.com/journal/MRP/2/12/10.61369/MRP.11880杨梦雪,唐雪峰

2024

212

2024-12-20

骨肉瘤作为骨骼系统恶性程度最高的肿瘤之一，其临床治疗仍以手术联合化疗为主，但转移性患者的生存率长期未见突破。传统啮齿类模型虽广泛用于基础研究，但在模拟人类肿瘤微环境、转移机制及药物代谢等方面存在显著局限性。本文聚焦于鸡胚绒毛尿囊膜（CAM）、猪及犬等非啮齿类模型的转化潜力，并探讨人工智能（AI）技术在优化模型构建、数据分析及治疗开发中的协同作用。通过整合多组学数据、AI驱动的影像分析及智能药物筛选，这些模型为解析疾病分子机制及加速新疗法开发提供了多维平台，具有重要的临床转化价值。骨肉瘤,非啮齿类动物模型,人工智能,骨肉瘤,转化医学

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