<?xml version="1.1" encoding="utf-8"?>
<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">MRP</journal-id><journal-title-group><journal-title>Medical Research and Practice</journal-title></journal-title-group><issn>2993-9690</issn><eissn>2993-9704</eissn><publisher><publisher-name>Art and Technology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/MRP.10015</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>天然磷脂和合成磷脂及其衍生物在药品生产中的应用</title><url>https://artdesignp.com/journal/MRP/2/10/10.61369/MRP.10015</url><author>张瑞娜,常娅娅,李静,钟丛丛,刘寒静,张小燕</author><pub-date pub-type="publication-year"><year>2024</year></pub-date><volume>2</volume><issue>10</issue><history><date date-type="pub"><published-time>2024-10-20</published-time></date></history><abstract>磷脂为含有元素磷的脂质，其分子结构中含亲水性基团和亲脂性支链，是具有表面活性的两亲性分子，可作为脂溶性药物生产中的乳化剂、增溶剂或脂质体赋形剂。相对于合成磷脂而言，天然磷脂来源于可再生资源，且生产、纯化工艺对环境更加友好，因此在口服制剂、真皮和非肠道用药制剂包括脂质体中应该十分广泛；合成磷脂的使用率则较低。在选择药物制剂的磷脂赋形剂方面，天然磷脂的优势更加明显，一方面其质量重现性良好，商品成本较低，另一方面天然磷脂来源于动物源，其安全性更容易被监管机构接受。为了避免在药物开发和生产过程中出现规模扩大的问题，应尽可能选择天然磷脂赋形剂而不是合成磷脂。</abstract><keywords>天然磷脂,合成磷脂,DSPC,GPC,甘露醇,蛋黄卵磷脂,脂质体注射液,注射用乳剂,纳米胶束</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>[1]Shurtleff, W., Aoyagi, A., History of Soy Lecithin[2]李继．磷脂的分离、改性及其在脂质体药物制剂中的应用研究［D］．甘肃：中国科学院兰州化学物理研究所，2009[3]Claire Gu&amp;eacute;guen, Thibaut Ben Chimol, Margaux Briand, Kassandra Renaud,M&amp;eacute;lodie Seiler, Morgane Ziesel, Patrick Erbacher, Malik Hellal,Evaluating how cationic lipid affects mRNA-LNP physical properties and biodistribution,European Journal of Pharmaceutics and Biopharmaceutics, 2023[4]Pankaj Singla, Rakesh Kumar Mahajan,Unusual solubilization capacity of hydrophobic drug olanzapine in polysorbate micelles for improved sustained drug release,Journal of Molecular Liquids,Volume 359,2022,119256,ISSN 0167-7322,[5]Genoveva Morral-Ru&amp;iacute;z, Mar&amp;iacute;a Jos&amp;eacute; Garc&amp;iacute;a-Celma,Polyurethane and polyurea nanoparticles based on polyoxyethylene castor oil derivative surfactant suitable for endovascular applications,International Journal of Pharmaceutics,Volume 461, Issues 1&amp;ndash;2,2014,Pages 1-13,[6]Shimojo, T., Abe, M., Ota, M., A method for determination of saturated phosphatidylcholine. J. Lipid Res. 1974, 15, 525&amp;ndash;527.[7]国家统计局，中国统计年鉴― 2022[8]Wendel, A., in: Kirk, R. E., Othmer, D. F. (Eds.), Kirk ‐Othmer Encyclopedia of Chemical Technology, John Wiley &amp;amp;Sons, Inc., New York, Chichester, Weinheim, Brisbane, Singapur, Toronto 1995, pp. 191&amp;ndash;210.[9] 周婧．高纯度蛋黄卵磷脂的制备工艺［D］．北京化工大学，2011.[10]Christopher Rupp, Hartwig Steckel, Bernd W. M&amp;uuml;ller,Solubilization of poorly water-soluble drugs by mixed micelles based on hydrogenated phosphatidylcholine, International Journal of Pharmaceutics,Volume 395, Issues 1&amp;ndash;2,2010,Pages 272-280,[11]Davis P F.Process for the hydrogenation of phosphatides.1962[12]Lekim, D., The resorption of lecithin administered orally and its physiologic implications, in: Soya Lecithin: Nutritional and Clinical Aspects: Proceedings of the First International Colloquium Held in Rome, Italy, Nov. 22, 1980, Cairella, M.,Lekim, D. (Eds.), Societa Editrice Universo, Rome 1981, pp. 21&amp;ndash;33.[13]Hama, S., Ogino, C. &amp;amp; Kondo, A. Enzymatic synthesis and modification of structured phospholipids: recent advances in enzyme preparation and biocatalytic processes. Appl Microbiol Biotechnol 99, 7879&amp;ndash;7891 (2015)[14]Adlercreutz D, Budde H, Wehtje E (2002) Synthesis of phosphatidylcholine with defined fatty acid in the sn-1 position by lipase-catalyzed esterification and transesterification reaction. Biotechnol Bioeng 78:403&amp;ndash;411[15]Shin-ya Morita, Yoshito Ikeda,Regulation of membrane phospholipid biosynthesis in mammalian cells,Biochemical Pharmacology,Volume 206,2022,115296[16]Huang, Q., Lei, H., Ding, L.et al.Stimulated phospholipid synthesis is key for hepatitis B virus replications.Sci Rep 9, 12989 (2019).[17]Anatoly N. Pinchuk, Boris I. Mitsner, Vitaly I. Shvets, Synthesis of enantiomerically pure ether lipid analogues from d-mannitol, Chemistry and Physics of Lipids Volume 65, Issue 1, 1993, Pages 65-75[18]Shota Nakata, Mamoru Hio, Ryuichi Takase, Shigeyuki Kawai, Daisuke Watanabe, Wataru Hashimoto,Polyunsaturated fatty acids-enriched lipid from reduced sugar alcohol mannitol by marine yeast Rhodosporidiobolus fluvialis Y2,Biochemical and Biophysical Research Communications,Volume 526, Issue4,2020,Pages 1138-1142[19]Synthesis of Multiacyl Poly(ethylene glycol) for the Conjugation of Cytochrome c to Phospholipid Vesicle Haruki Ohkawa, Yuji Teramura, Shinji Takeoka, and Eishun Tsuchida Bioconjugate Chemistry 2000 11 (6), 815-821[20]MacDonald, R. C., Rakhmanova, V. A., Choi, K. L., Rosenzweig, H. S., Lahiri, M. K., O ‐Ethylphosphatidylcholine: A metabolizable cationic phospholipid which is a serumcompatible DNA transfection agent. J. Pharm. Sci. 1999, 88, 896&amp;ndash;904.[21]Babak Kaboudin, Hiroshi Aoyama, Akihiro Sugiyama, Yoko Endo-Takahashi, and Yoichi Negishi Organic Phase-Soluble Nanomagnetically Cationic Phospholipid: Synthesis, Characterization, and In Vitro Transfection Activity ACS Applied Materials &amp;amp; Interfaces 2023 15 (28), 33437-33443[22]Blom, D.J., Raal, F.J., Santos, R.D. et al. Lomitapide and Mipomersen&amp;mdash;Inhibiting Microsomal Triglyceride Transfer Protein (MTP) and apoB100 Synthesis. Curr Atheroscler Rep 21, 48 (2019).[23]Fahima Dilnawaz*Polymeric Biomaterial and Lipid Based Nanoparticles for Oral Drug DeliveryVolume 24, Issue 22, 2017Page: [2423 - 2438][24]Mahajan, M., Kaur, M., Thakur, S. et al. Solid Lipid Nanoparticles as Carrier to Increase Local Bioavailability of Acitretin After Topical Administration in Psoriasis Treatment. J Pharm Innov 18, 220&amp;ndash;237 (2023)[25]Gregory, T. J., Steinberg, K. P., Spragg, R., Gadek, J. E.et al., Bovine surfactant therapy for patients with acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 1997, 155, 1309&amp;ndash;1315.[26]Geller, D. E., Weers, J., Heuerding, S., Development of an inhaled dry ‐ powder formulation of tobramycin using Pulmo- Sphere technology. J. Aerosol Med. Pulm. Drug Deliv. 2011, 24, 175&amp;ndash;182.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
