[1] Falcone D, Uzunbajakava N E, Varghese B, et al. Microspectroscopic Confocal Raman and Macroscopic Biophysical Measurements in the in vivo Assessment of the Skin Barrier: Perspective for Dermatology and Cosmetic Sciences[J]. Skin Pharmacology and Physiology, 2015, 28(6):307-317. [2] Stamatas G N, Sterke J D, Hauser M, et al. Lipid uptake and skin occlusion following topical application of oils on adult and infant skin[J]. Journal of Dermatological Science, 2008, 50(2):135-142. [3] P J Caspers, G W Lucassen, E A Carter et al. In vivo confocal Raman microspectroscopy of the skin: noninvasive determination of molecular concentration profiles[J]. J Journal of Investigative Dermatology, 2001, 116(3):434-42. [4] Choe C S, Lademann Jürgen, Darvin M E.Depth profiles of hydrogen bound water molecule types and their relation to lipid and protein interaction in the human stratum corneum in vivo[J].Analyst, 2016, 141(22):6329-6337. [5] Vyumvuhore R, Tfayli A, Biniek K, et al.The relationship between water loss, mechanical stress, and molecular structure of human stratum corneum ex vivo[J].Journal of Biophotonics, 2015, 8(3):217-225. [6] Vyumvuhore R, Tfayli A, Duplan Hélène, et al. Effects of atmospheric relative humidity on Stratum Corneum structure at the molecular level: ex vivo Raman spectroscopy analysis[J]. Analyst, 2013, 138(14):4103-11. [7] ChunSik Choe, Johannes Schleusener, Jürgen Lademann et al. In vivo confocal Raman microscopic determination of depth profiles of the stratum corneum lipid organization influenced by application of various oils[J]. Journal of Dermatological Science, 2017, 87( 2):183-191. [8] ChunSik Choe, Jürgen Lademann, Maxim E Darvin. A depthdependent profile of the lipid conformation and lateral packing order of the stratum corneum in vivo measured using Raman microscopy[J]. Analyst, 2016, 141: 1981-7. [9] Van L M D A, Domínguez-Hüttinger Elisa, Stamatas G N, et al. Resistance to Water Diffusion in the Stratum Corneum Is Depth- Dependent[J]. Plos One, 2015, 10(2):e0117292. [10] Choe C S, Schleusener J, Jürgen Lademann, et al. Keratin-water- NMF interaction as a three layer model in the human stratum corneum using in vivo confocal Raman microscopy[J].Scientific Reports, 2017, 7(1):15900. [11] Koppes S A, Kemperman P, Van Tilburg I, et al. Determination of natural moisturizing factors in the skin: Raman microspectroscopy versus HPLC[J]. Biomarkers, 2017, 22(1-8):502-507. [12] Kroll L M, Hoffman D R, Cunningham C, et al. Impact of stratum corneum damage on natural moisturizing factor （NMF） in the skin[M]. Treatment of Dry Skin Syndrome, 2012: 441-451. [13] dos Santos, LauritaTippavajhala, Vamshi KrishnaMendes, et al. Evaluation of penetration process into young and elderly skin using confocal Raman spectroscopy[J].Vibrational Spectroscopy: An International Journal devoted to Applications of Infrared and Raman Spectroscopy, 2019, 100. [14] Fukuda K, Ito Y, Furuichi Y, et al. Three stepwise pH progressions in stratum corneum for homeostatic maintenance of the skin[J]. Nature Communications, 2024, 15(1):4062. [15] Bielfeldt S, Schoder V, Ely U, et al.Assessment of human stratum corneum thickness and its barrier properties by in ‐vivo confocal Raman spectroscopy[J]. International Journal of Cosmetic Science, 2010, 31(6):479-480. [16] Tippavajhala V K, Magrini T D, Matsuo D C, et al. In Vivo Determination of Moisturizers Efficacy on Human Skin Hydration by Confocal Raman Spectroscopy[J]. AAPS PharmSciTech, 2018, 19(7):3177-3186. [17] Zhang L, Cambron T, Niu Y, et al. MCR Approach Revealing Protein, Water and Lipid Depth Profile in Atopic Dermatitis Patients’ Stratum Corneum via in Vivo Confocal Raman Spectroscopy[J]. Analytical Chemistry, 2019, 91(4):2784-2790 . [18] Egawa M, Kunizawa N, Hirao T, et al. In vivo characterization of the structure and components of lesional psoriatic skin from the observation with Raman spectroscopy and optical coherence tomography: A pilot study[J]. Journal of Dermatological Science, 2010, 57(1):66-69. [19] Agnieszka K. Dąbrowska, Adlhart C, Spano F, et al. In vivo confirmation of hydration-induced changes in human-skin thickness, roughness and interaction with the environment[J]. Biointerphases, 2016, 11(3):031015. [20] Crowther J M, Sieg A, Blenkiron P, et al.Measuring the effects of topical moisturizers on changes in stratum corneum thickness, water gradients and hydration in vivo[J]. British Journal of Dermatology, 2010, 159(3):567-577. [21] 何一凡，吴文海，苏牧楠，蒋晓龙，刘宇红．拉曼光谱研究 表面活性剂对皮肤刺激和皮肤防护的体内分子机制[J]. 日用化学工 业（中英文）, 2024, 54(4): 401-409.