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<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">CDCST</journal-id><journal-title-group><journal-title>China Daily Chemical Science Technology</journal-title></journal-title-group><issn>2997-7096</issn><eissn>2997-710X</eissn><publisher><publisher-name>Art and Technology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/CDCST.2026030014</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>UVA诱导皮肤皱纹产生的信号通路及护肤品靶向干预策略研究进展</title><url>https://artdesignp.com/journal/CDCST/3/3/10.61369/CDCST.2026030014</url><author>陶慧霞,刘一蕊,邱泓晟,许凤兰,朱伟</author><pub-date pub-type="publication-year"><year>2026</year></pub-date><volume>3</volume><issue>3</issue><history><date date-type="pub"><published-time>2026-09-25</published-time></date></history><abstract>长期暴露于紫外线会导致皮肤光老化从而产生皱纹，此类皱纹皱痕深陷且不易消退。从组织学角度看，其伴随有表皮结构损伤、胶原蛋白流失以及弹性纤维变性堆积等特征。这些皱纹一旦生成，通常很难实现自然修复。因此，本文系统综述了UVA导致皱纹的相关信号通路，包括MAPK、NF-&amp;kappa;B和TGF-&amp;beta;信号通路，以及各通路之间的交互调控网络。本文还阐述了目前已有的干预策略与靶点，梳理了作用于相应靶点的植物提取物并分类总结。清晰的靶点策略可以给护肤品的配方设计提供选择和思路。</abstract><keywords>抗皱,UVA,信号通路,抗氧化,植物提取物</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>[1] 王刘祥. UVA辐射对人皮肤成纤维细胞的过氧化损伤及EGCG的保护作用[D]. 浙江: 浙江大学, 2013.
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