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<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">CDCST</journal-id><journal-title-group><journal-title>China Daily Chemical Science Technology</journal-title></journal-title-group><issn>2997-7096</issn><eissn>2997-710X</eissn><publisher><publisher-name>Art and Technology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/CDCST.2026020023</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>V型胶原蛋白及A型重组V型人源化胶原蛋白的研究进展与应用展望</title><url>https://artdesignp.com/journal/CDCST/3/2/10.61369/CDCST.2026020023</url><author>孟宪瑶,张艺,陈传秀</author><pub-date pub-type="publication-year"><year>2026</year></pub-date><volume>3</volume><issue>2</issue><history><date date-type="pub"><published-time>2026-06-25</published-time></date></history><abstract>V型胶原蛋白（COLV）是细胞外基质中的关键调节性纤维胶原，随着对COLV结构-功能研究的深入及合成生物学的发展，A型重组V型人源化胶原蛋白的制备成为可能。本文系统综述了天然COLV的分子结构特征及皮肤生物学功能，并探讨了A型重组V型人源化胶原蛋白的生物合成机制及多元化应用前景。目前A型重组V型人源化胶原蛋白与天然COLV在结构完整性和功能等同性方面仍存在差异，其应用仍需进一步验证。</abstract><keywords>V型胶原蛋白,A 型重组人源化,生物合成,生物学功能,护肤应用</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>[1]Jordi Bella,David J. 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