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<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">CDCST</journal-id><journal-title-group><journal-title>China Daily Chemical Science Technology</journal-title></journal-title-group><issn>2997-7096</issn><eissn>2997-710X</eissn><publisher><publisher-name>Art and Technology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/CDCST.2026020022</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>重组胶原蛋白的透皮递送技术及其在化妆品中的应用</title><url>https://artdesignp.com/journal/CDCST/3/2/10.61369/CDCST.2026020022</url><author>张慧荣,王正奇,严娟娟,陈传秀</author><pub-date pub-type="publication-year"><year>2026</year></pub-date><volume>3</volume><issue>2</issue><history><date date-type="pub"><published-time>2026-06-25</published-time></date></history><abstract>胶原蛋白作为真皮层主要结构蛋白，通过维持皮肤弹性、张力与保水能力，对维系皮肤组织结构完整性及延缓皮肤老化具有关键作用。受分子特性限制，胶原蛋白在化妆品应用中存在难以穿透皮肤角质层、透皮效率受屏障功能制约的核心瓶颈。经皮靶向递送技术是破解该难题的关键手段，通过微乳、脂质体、超分子、微球等技术，可提升透皮性与靶向性，实现长效精准递送，拓展应用边界并推动相关技术在化妆品应用中的发展。</abstract><keywords>胶原蛋白,透皮吸收,递送技术</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>[1] Ricard-Blum S. The collagen family[J]. Cold Spring Harb PerspectBiol, 2011,3(1):a004978.[2] 马雅倩,张海灵.胶原蛋白的结构、生物功能与跨领域应用进展综述[J]. 山东化工,2026,55(02):116-120.[3] 李亚茹,孙畅,刘子滨, 等.不同类型胶原蛋白在皮肤衰老中的作用及其研究进展[J]. 生物工程学报,2026,42(02):533-546.[4] Chanut-Delalande H, Bonod-Bidaud C, Cogne S, et al.Development of a functional skin matrix requires deposition of collagenV heterotrimers[J]. Mol Cell Biol, 2004,24(13):6049-6057.[5] 王啸尘,黄伟,刘英杰, 等.重组胶原蛋白的不同表达体系研究进展[J]. 山东化工,2026,55(01):99-104.[6] 龙存林,张敏娟,任戬, 等.重组胶原蛋白在医疗器械领域的应用进展[J]. 中国医疗器械杂志,2025,49(06):640-646.[7] 夏煌慧,黄建忠.重组胶原蛋白的生物合成研究进展[J].微生物学报,2025,65(05):1939-1957.[8] Maeda N, Jiao H, Kłosowska-Chomiczewska IE, et al. NanoparticleSkin Penetration: Depths and Routes Modeled In-Silico[J]. Small.2025,21(20):e2412541.[9] Souto EB, Cano A, Martins-Gomes C, et al. Microemulsions andNanoemulsions in Skin Drug Delivery[J]. Bioengineering (Basel),2022,9(4):158.[10] Callender SP, Mathews JA, Kobernyk K, et al. Microemulsionutility in pharmaceuticals: Implications for multi-drug delivery[J]. Int JPharm, 2017,526(1-2):425-442.[11] Szumała P, Jungnickel C, Kozłowska-Tylingo K, et al. Transdermaltransport of collagen and hyaluronic acid using water in oil microemulsion[J]. Int J Pharm, 2019,572:118738.[12] 山西锦波生物医药股份有限公司.一种油溶胶原蛋白及其制备方法和应用:202511793904.9[P].2026-01-20.[13] 北京择美科技有限公司.一种含重组胶原蛋白微乳液的医用敷贴及其制备方法:202511112653.3[P].2025-10-14.[14] 杨桂明,谷健梅,宋丽艳.脂质体技术在化妆品制剂中的应用[J]. 中国美容医学,2009,18(03):396-398.[15] 闫森,樊君,谭春雷.脂质体包裹胶原蛋白的制备及其透皮性能[J]. 精细化工,2012,29(06):576-579.[16] 李萌.胶原蛋白功能特性与脂质体制剂透皮性能研究[D].天津科技大学,2023.[17] Du M, Chen C, Zhou Y, et al. Preparation, characterization andantioxidative activity analysis of recombinant humanized collagen typeIII-loaded liposomes[J]. Sci Rep, 2025,15(1):26907.[18] Lee MS, Bui HD, Kim SJ, et al. Liposome-assisted penetration andantiaging effects of collagen in a 3D skin model[J]. J Cosmet Dermatol,2024,23(1):236-243.[19] Li M, Li M, Li X, et al. Preparation, Characterization and ex vivoSkin Permeability Evaluation of Type I Collagen-Loaded Liposomes[J].Int J Nanomedicine, 2023,18:1853-1871.[20] Wang J, Li M, Duan L, et al. Deep Eutectic Systems as NovelVehicles for Assisting Drug Transdermal Delivery. Pharmaceutics,2022;14(11):2265.[21] Q. M.Qi, M.Duffy, A. M.Curreri, et al.Mitragotri, Comparison ofIonic Liquids and Chemical Permeation Enhancers for TransdermalDrug Delivery[J]. Adv. Funct. Mater, 2020, 30, 2004257.[22] 予态(上海)生物科技有限公司,深圳市萱嘉生物科技有限公司.一种超分子重组超聚体胶原蛋白及其制备方法和应用:202211364064.0[P].2024-09-03.[23] 黄佳,马晓钰,鲁朝刚, 等.超分子技术在化妆品中的应用与展望[J]. 日用化学品科学,2025,48(02):84-88.[24] 江南美湾(无锡)健康科技有限公司.一种重组XVII型胶原蛋白与腺苷共晶物的制备方法及其应用:202411853633.7[P].2025-03-18.[25] 熊新,李炜钊,杨育灿, 等.基于胶原蛋白的多孔微球制备及应用研究进展[J]. 高分子材料科学与工程,2022,38(11):183-190.[26] 李宗浩.超重力乳化法制备再生医学用PLLA微球及其性能研究[D]. 北京化工大学,2025.[27] 上海臻臣化妆品有限公司.水解胶原蛋白冻干微球及其制备方法和应用:202511871709.3[P].2026-01-09.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
