CDCSTChina Daily Chemical Science Technology2997-70962997-710XArt and Technology10.61369/CDCST.2026020016Article结冷胶制备固体凝胶喷雾及其性能评价https://artdesignp.com/journal/CDCST/3/2/10.61369/CDCST.2026020016陈思洋,颜雪娇,蒲云月,谢丹,张云2026322026-06-25针对传统液态喷雾保湿留驻时间短、易流淌及常规凝胶厚重不便携等痛点，本研究选用具有“剪切变稀-瞬间雾化”特性的低酰基结冷胶（LA-GG），发展了固体凝胶喷雾概念。采用L₁₆(4⁵)正交试验，以结冷胶（A）、氯化钠（B）、1,3- 丁二醇（C）、海藻糖（D）、甘草酸二钾（E）为因素，凝胶状态、外观、高低温稳定性及喷雾效果为评价指标。极差分析显示因素显著性排序为A>B>C>D>E，确定最优配方A4B2C3D1E4：结冷胶0.4%、氯化钠0.8%、1,3-丁二醇6%、海藻糖1%、甘草酸二钾0.4%。性能测试表明：pH5.35符合皮肤生理范围；耐热（37~50℃）、耐寒（-4~4℃）稳定性良好；受试者（n=15）使用120 min后角质层含水量提升47.26%（P<0.001），TEWL降低25.71%（P=0.01）。该配方兼具凝胶锁水与喷雾便携优势，为新一代保湿喷雾提供配方依据。低酰基结冷胶,固体凝胶喷雾,正交试验,保湿性能

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