CDCSTChina Daily Chemical Science Technology2997-70962997-710XArt and Technology10.61369/CDCST.2026020007Article基于皮肤模型评价VC乙基醚与乙酰酪氨酸的协同美白效应及其对原型VC的优势https://artdesignp.com/journal/CDCST/3/2/10.61369/CDCST.2026020007徐思伟,周彪,林琳,陈丽,王蕊蕊,陆毅2026322026-06-25通维生素C（Vitamin C，抗坏血酸）虽具有卓越的美白与抗氧化功效，但其原型在水溶液中极不稳定，限制了应用。为此，本研究探讨了由2% 维生素C乙基醚（3-O-乙基抗坏血酸，VC乙基醚，一种高稳定、高透皮的VC衍生物）与1%乙酰酪氨酸构成的复配体系。研究发现，乙酰酪氨酸能有效缓冲VC乙基醚水溶液在高温（45℃）加速试验中出现的pH下降现象。基于MelaKutis® 3D黑素皮肤模型的功效评价表明，该复配体系在提升模型亮度（L*值）和抑制黑素生成方面的效果，均显著优于3%及5%的原型VC水溶液。本研究为开发兼具高稳定性与高效能的美白护肤品提供了新的配方策略与实验依据。维生素C乙基醚,乙酰酪氨酸,原型维生素C,化学稳定性,美白功效,3D 皮肤模型

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