<?xml version="1.1" encoding="utf-8"?>
<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">CDCST</journal-id><journal-title-group><journal-title>China Daily Chemical Science Technology</journal-title></journal-title-group><issn>2997-7096</issn><eissn>2997-710X</eissn><publisher><publisher-name>Art and Technology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/CDCST.2026020003</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>一款抗皱紧致精华霜的皮肤改善效果评价</title><url>https://artdesignp.com/journal/CDCST/3/2/10.61369/CDCST.2026020003</url><author>陈鑫,王晓娜,宁辉,韩婷婷,杨瑞娟,林娣</author><pub-date pub-type="publication-year"><year>2026</year></pub-date><volume>3</volume><issue>2</issue><history><date date-type="pub"><published-time>2026-06-25</published-time></date></history><abstract>利用体外抗皱、紧致及人体功效评价试验对一款抗皱紧致精华霜的功效性进行综合评价。通过对产品在人皮肤成纤维细胞（Human Dermal Fibroblasts，HSF）和人永生化角质细胞（HumanImmortalized Epidermal Cells，HaCaT）模型上进行Ⅰ、Ⅲ、Ⅳ、Ⅶ、ⅩⅦ型胶原蛋白、层黏连蛋白（Laminin，LN）含量测定，透明质酸合酶HAS1、HAS2基因表达量测试；以及人体面部提升光泽度、抗皱、紧致功效试验，表明该精华霜具有显著的抗皱紧致功效。</abstract><keywords>精华霜,抗皱,紧致,体外和人体功效评价</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>[1]L&amp;oacute;pez-Ot&amp;iacute;n C, Blasco M A, Partridge L, et al. Hallmarks of aging:An expanding universe[J]. Cell, 2023, 186(2): 243-278.[2]杜克斯,李泽巧,张宝江, 等.面部皮肤衰老的外观变化及形成因素[J]. 日用化学工业,2022,52(02):199-206.[3]Kim M, Park H J. Molecular mechanisms of skin aging and rejuvenation[J]. Molecular mechanisms of the aging process and rejuvenation,2016, 450.[4]Iannitti T, Morales-Medina J C, Coacci A, et al. Experimental andclinical efficacy of two hyaluronic acid-based compounds of differentcross-linkage and composition in the rejuvenation of the skin[J]. Pharmaceuticalresearch, 2016, 33: 2879-2890.[5]蒋玉.鲟鱼鳔胶原蛋白延缓皮肤自然衰老作用及分子机制研究[D]. 江苏大学,2019.[6]李小静,黄虎,陶侃, 等.生物活性多肽在美容护肤领域应用及技术研究进展[J]. 中国化妆品,2023(03):116-121.[7]Wang A S, Dreesen O. Biomarkers of cellular senescence and skinaging[J]. Frontiers in genetics, 2018, 9: 247.[8]Zhao X, Zhang X, Liu D. Collagen peptides and the related syntheticpeptides: A review on improving skin health[J]. Journal of FunctionalFoods, 2021, 86: 104680.[9]李惠玲,周春霞,章漳.细梗蔷薇愈伤组织提取物在人真皮成纤维细胞及3D表皮模型上的护肤功效探究[J].日用化学工业(中英文),2023,53(03):300-307.[10]Rousselle P, Laigle C, Rousselet G. The basement membrane inepidermal polarity, stemness, and regeneration[J]. American Journal ofPhysiology-Cell Physiology, 2022, 323(6): C1807-C1822.[11]Zhang Y, Huang G, Zhang Z, et al. Protective effects of a novelFS-Collagen hydrolysates against UV-and d-galactose-induced skinaging[J]. Food Science and Biotechnology, 2025, 34(1): 257-267.[12]Vassal-Stermann E, Duranton A, Black A F, et al. A New C-Xylosideinduces modifications of GAG expression, structure and functionalproperties[J]. PLoS One, 2012, 7(10): e47933.[13]李诚桐,赵华,王敏.化妆品功效评价( Ⅸ )&amp;mdash;&amp;mdash; 图像分析法在化妆品功效评价中的应用[J]. 日用化学工业,2018,48(10):551-557.[14]彭蕴,姜浩敏,刘雨菲, 等.神经递质抑制类肽淡化面部动态皱纹作用机理及研究进展[J]. 香料香精化妆品,2023(04):30-36.[15]李汇柯,冯楠,王闻博, 等.皮肤糖化反应发生机制、影响因素及抗糖化在化妆品行业中的发展现状[J].日用化学工业,2021,51(02):153-160.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
