<?xml version="1.1" encoding="utf-8"?>
<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">CDCST</journal-id><journal-title-group><journal-title>China Daily Chemical Science Technology</journal-title></journal-title-group><issn>2997-7096</issn><eissn>2997-710X</eissn><publisher><publisher-name>Art and Technology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/CDCST.2026010029</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>化妆品防腐剂的研究进展、挑战与未来趋势</title><url>https://artdesignp.com/journal/CDCST/3/1/10.61369/CDCST.2026010029</url><author>蒲云月,张云</author><pub-date pub-type="publication-year"><year>2026</year></pub-date><volume>3</volume><issue>1</issue><history><date date-type="pub"><published-time>2026-03-05</published-time></date></history><abstract>本文系统梳理了传统防腐剂的局限性及全球监管趋势，重点分析了天然来源防腐等效剂、新型化学&amp;ldquo;防腐剂&amp;rdquo;、物理防腐技术及多元复配体系等新型防腐策略的研究进展。同时，探讨了当前行业在安全性评估、法规滞后及消费者认知等方面面临的主要挑战，并对未来绿色化、智能化及法规协同化发展方向进行了展望。</abstract><keywords>化妆品防腐剂,安全性,天然防腐剂,防腐体系,法规,研究进展</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>[1] 何小平,李忠伟,刘玮. 化妆品微生物学与微生物控制技术[M].北京: 化学工业出版社,2018:45-48.[2] 国家药品监督管理局. 化妆品安全技术规范(2015年版)[S]. 北京: 中国标准出版社,2015.[3] SCCS (Scientific Committee on Consumer Safety). Opinion on Parabens[S]. Luxembourg: Publications Office of the European Union,2021: SCCS/1624/2020.[4] BILAL M, IQBAL H M N, BARCELO D. Mitigating the risk of methylisothiazolinone contact allergies in cosmetic products: A science-based review[J]. Journal of Cosmetic Dermatology, 2020,19(1): 100-107.[5] 董银卯,孟宏,邱显荣. 化妆品配方设计7 步[M]. 北京:化学工业出版社,2019:112-115.[6] 唐健,王敏. 绿色化妆品防腐剂的研究进展与发展趋势[J]. 日用化学工业,2022, 52(1): 54-61.[7] SONI M G, CARABIN I G, BURDOCK G A. Safety assessment of esters of p-hydroxybenzoic acid (parabens)[J]. Food and Chemical Toxicology, 2005, 43(7): 985-1015.[8] DARBRE P D, ALJARRAH A, MILLER W R, et al. Concentrations of parabens in human breast tumours[J]. Journal of Applied Toxicology, 2004, 24(1): 5-13.[9] Scientific Committee on Consumer Safety. Opinion on parabens[R]. SCCS/1348/11, 2011.[10] BOTTENBERG P, DEL CASTILHO A, DE MUYNCK C, et al. Formaldehyde-releasing preservatives in cosmetics: an update on their chemistry, safety and regulation[J]. International Journal of Cosmetic Science, 2018, 40(5): 425-435.[11] ZACHARIAE C, ENGELSKJON T, MENN&amp;Eacute; T, et al.Formaldehyde allergy and exposure to formaldehyde-releasing biocides: a clinical study[J]. Contact Dermatitis, 2003, 49(3): 124-128.[12] DEKOVEN J G, WARSHAW E M, BELSTIO D V, et al. North American Contact Dermatitis Group patch test results: 2015-2016[J]. Dermatitis, 2018, 29(6): 297-309.[13] 国家药品监督管理局. 化妆品安全技术规范[S]. 2022.[14] 张宏伟,王静,孙鹏. 工业杀菌剂异噻唑啉酮类化合物的应用与发展[J]. 工业水处理,2010, 30(5): 1-5.[15] ESSCA. The European Surveillance System of Contact Allergies (ESSCA): results of patch testing the standard series, 2009-2012[J].Journal of the European Academy of Dermatology and Venereology,2015, 29(9): 1781-1789.[16] 王学民,李静,谈益妹, 等. 甲基异噻唑啉酮致面部接触性皮炎1232例斑贴试验结果分析[J]. 中华皮肤科杂志,2016, 49(5): 341-344.[ 1 7 ] B R U Z E M , E N G F E L D T K , G O O S S E N S A , e t a l .Methylisothiazolinone: the rise and fall of a contact allergen[J]. Contact Dermatitis, 2014, 71(2): 65-71.[18] DU S, LI H, CUI Y, et al. Methylisothiazolinone induces apoptosis in HaCaT cells via ROS-mediated mitochondrial pathway[J]. Journal of Applied Toxicology, 2019, 39(6): 844-854.[19] LI H, YUAN Y, FU H, et al. Methylisothiazolinone induces neurotoxicity in HT-22 cells by triggering MIEF1-related mitochondrial fission and activation of the mitochondrial apoptosis pathway[J]. Ecotoxicology and Environmental Safety, 2021, 208:111607.[20] 国家药品监督管理局. 国家药监局关于发布《化妆品安全技术规范（2022年版）》的公告（2022年第36号）[EB/OL]. (2022-04-25)[2023-10-27].[21] 国务院. 化妆品监督管理条例:中华人民共和国国务院令第727 号[A/OL]. (2020-06-29)[2023-10-27].[22] 王丽,张伟,李强. 肉桂精油及其主要成分的抗菌活性研究[J].食品工业科技,2019, 40(12): 115-119, 125.[23] HAMMER K A, CARSON C F, RILEY T V. Antimicrobial activity of essential oils and other plant extracts[J]. Journal of Applied Microbiology, 1999, 86(6): 985-990.[24] 刘洋,陈卫东,郭晓晖. 百里香精油化学成分及其抗真菌活性研究[J]. 中国药学杂志,2018, 53(5): 353-357.[25] 赵静,李明,高飞. 迷迭香提取物的化学成分及其在化妆品中的防腐抗氧化协同作用[J]. 香料香精化妆品,2021(2): 45-49.[26] 陈志强,刘红梅,谢丽霞. 厚朴酚对痤疮丙酸杆菌的抗菌活性及其机制初探[J]. 中国药学杂志,2017, 52(14): 1257-1261.[27] 国家药典委员会. 中华人民共和国药典:一部[M]. 2020 版. 北京: 中国医药科技出版社,2020:315-316.[28] 李宏伟,王静,孙宝国. &amp;epsilon;-聚赖氨酸在化妆品中的防腐应用研究[J]. 日用化学工业,2019, 49(7): 456-461.[29] 王磊,陈卫,张灏. 纳他霉素与&amp;epsilon;-聚赖氨酸复配在精华液中的防腐效果评价[J]. 香料香精化妆品,2020(4): 65-69.[30] 张丽媛,董霞,谢静莉, 等. 微生物源溶菌酶的发酵生产及其在化妆品中的防腐性能研究[J]. 工业微生物,2018, 48(2): 1-7.[31] B O R N H &amp;Ouml; F T M , H I R O U S , R I C H T E R D , e t a l .Ethylhexylglycerin: a multifunctional ingredient for personal care[J].SOFW Journal, 2008, 134(5): 42-48.[32] 张伟,李静,王磊. 乙基己基甘油与苯氧乙醇复配体系的协同抗菌作用研究[J]. 日用化学工业,2015, 45(10): 571-574.[33] SCIENTIFIC COMMITTEE ON CONSUMER SAFETY (SCCS).Opinion on ethylhexylglycerin[S]. Luxembourg: European Commission,2013.[34] AULBACH R H, MITTAG H, KUMAR A. 1,2-Alkanediols: a novel class of cosmetic preservatives[J]. Cosmetics &amp;amp; Toiletries, 2009,124(11): 61-66.[35] GEIS P A, THORNE M T, KURTZ W J. Antimicrobial activity of 1,2-alkanediols[J]. Cosmetics &amp;amp; Toiletries, 2010, 125(12): 63-70.[36] 刘晓慧,陈华. 1,2-己二醇与1,2-戊二醇在化妆品中的防腐应用研究[J]. 香料香精化妆品,2017(4): 55-58.[37] PAPAGEORGIOU S, VARVARESOU A, TSIRIVAS E, et al. New preservative systems for cosmetics and toiletries[J]. Cosmetics, 2014,1(4): 220-232.[38] MEYER F, EBERLEIN B, KREFT D. Phenoxyethanol and hydroxyacetophenone: a synergistic preservative blend[J]. Cosmetics &amp;amp; Toiletries, 2012, 127(3): 186-192.[39] 王小雨,刘伟,陈志强. 超高压技术在功能性化妆品制备中的应用研究[J]. 食品与机械,2019, 35(7): 214-218.[40] G&amp;Oacute;MEZ-L&amp;Oacute;PEZ V M, RAGAERT P, DEBEVERE J, et al. Shelflife &amp;nbsp;extension of minimally processed carrots by gaseous chlorine dioxide[J]. International Journal of Food Microbiology, 2007, 116(2):221-227.[41] 蔡良根. 无菌制剂生产与质量控制[M]. 北京: 中国医药科技出版社,2017:145-150.[42] APPENDINI P, HOTCHKISS J H. Review of antimicrobial food packaging[J]. Innovative Food Science &amp;amp; Emerging Technologies,2002, 3(2): 113-126.[43] 刘晓曼,赵一凡. 化妆品包装的防污染设计研究[J]. 包装工程,2021, 42(14): 178-183.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
