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<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">CDCST</journal-id><journal-title-group><journal-title>China Daily Chemical Science Technology</journal-title></journal-title-group><issn>2997-7096</issn><eissn>2997-710X</eissn><publisher><publisher-name>Art and Technology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/CDCST.2026010023</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>环黄芪醇在皮肤领域的研究进展：从分子机制到递送技术</title><url>https://artdesignp.com/journal/CDCST/3/1/10.61369/CDCST.2026010023</url><author>丛远华,张宁</author><pub-date pub-type="publication-year"><year>2026</year></pub-date><volume>3</volume><issue>1</issue><history><date date-type="pub"><published-time>2026-03-05</published-time></date></history><abstract>介绍了CA在皮肤抗衰老、屏障修复、抗炎及美白中的作用机制及其递送技术研究进展。在分子机制层面，CA通过激活端粒酶逆转录酶延缓细胞衰老，并调控Nrf2/ARE、MAPK/NF-&amp;kappa;B等信号通路，增强皮肤抗氧化防御能力，抑制紫外线诱导的活性氧积累及基质金属蛋白酶表达，从而减少胶原降解。同时，CA有效提高UVB 损伤细胞中透明质酸水平和皮肤水合作用因子（filaggrin 和丝氨酸棕榈酰转移酶）的表达，改善皮肤弹性，维持皮肤健康。此外，CA通过调控TGF-&amp;beta;/Smad通路促进成纤维细胞增殖与Ⅰ /Ⅲ型胶原合成，协同PI3K/Akt/mTOR信号改善皮肤屏障功能，并通过抑制TLR4/NF-&amp;kappa;B通路下调IL-6、TNF-&amp;alpha;等促炎因子释放，在特应性皮炎及银屑病等炎症性皮肤病中展现治疗潜力。</abstract><keywords>环黄芪醇,纳米递送系统,皮肤老化,美白,抗氧化</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>[1]Chang YX, Ge AH, Donnapee S, et al The multi-targets integrated fingerprinting for screening anti-diabetic compounds from a Chinese medicine Jinqi Jiangtang Tablet [J]. 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