<?xml version="1.1" encoding="utf-8"?>
<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">CDCST</journal-id><journal-title-group><journal-title>China Daily Chemical Science Technology</journal-title></journal-title-group><issn>2997-7096</issn><eissn>2997-710X</eissn><publisher><publisher-name>Art and Technology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/CDCST.2026010020</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>海洋生物原料贻贝粘蛋白的代谢特性研究</title><url>https://artdesignp.com/journal/CDCST/3/1/10.61369/CDCST.2026010020</url><author>高敏,顾铭</author><pub-date pub-type="publication-year"><year>2026</year></pub-date><volume>3</volume><issue>1</issue><history><date date-type="pub"><published-time>2026-03-05</published-time></date></history><abstract>贻贝粘蛋白因具有抗炎、促愈合、长效抗氧化等功能在医疗产品、化妆品等日用消费中有着广泛的应用价值。贻贝粘蛋白发挥功能的同时，其代谢同特征直接关系原料的安全性。使用放射性同位素标记技术研究雌雄Sprague-Dawley（SD）大鼠单次直肠给予1.5mg/100&amp;mu;Ci/kg 的[3H]贻贝粘蛋白后，检测血浆中总放射性的药代动力学行为，以及[3H]贻贝粘蛋白在直肠黏膜的滞留情况。结果显示，在大鼠直肠给予放射性标记贻贝粘蛋白后168小时，直肠局部仍有放射性，血浆中贻贝粘蛋白的量远低于直肠局部，提示贻贝粘蛋白在局部长时间起效，具有较高的安全性。</abstract><keywords>贻贝粘蛋白,放射性标记,安全性</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>[1]Ziqi Liu, Min Jiang, Juemin Zhao, et al. Efficacy of a wound ‐dressing biomaterial on prevention of postinflammatory hyperpigmentation after suction blister epidermal grafting in stablevitiligo patients: a controlled assessor ‐blinded clinical study with in vitro bioactivity investigation [J]. Archives of Dermatological&amp;nbsp;Research, 2020, 312(9):635-645.[2]Richeng Dong，Jiachen Yuan ，Zhehu Jin, et al. Mussel adhesive&amp;nbsp; protein treatment delivered by microneedling for sensitive skin: A clinical study [J]. Journal of Cosmetic Dermatology, 2023(00):1-9.[3]韦莹婷，杨宾烈，黄莉霞，等.贻贝粘蛋白敷料在宫颈 LEEP 术后创面修复及阴道微生态恢复中的应用[J].国际妇产科学杂志, 2022, 49(5):507-510.[4]费烨，王韵，沈征宇，等.贻贝粘蛋白在微等离子体治疗痤疮凹陷性瘢痕后的应用[J]. 临床皮肤科杂志, 2015, 44(1): 40-42.[5]于东宁，张国安，顾铭.贻贝粘蛋白治疗瘢痕瘙痒的临床研究[J]. 中华损伤与修复杂志, 2013, 8(6):39-41.[6]Sander Haemersa, Mieke C. van der Leedenb, et al. Coil dimensions of the mussel adhesive protein Mefp-1[J]. Biomaterials 2005,26: 1231&amp;ndash;1236.[7]Haeshin Lee, Norbert F. Scherer, Phillip B. Messersmith. Singlemolecule mechanics of mussel adhesion[J]. Pnas, 2006,103 (35):12999&amp;ndash;13003.[8]J. Herber Waitet, Marvin L. Tanzer. Polyphenolic substance of Mytilus edulis Novel adhesive containing L- DOPA and hydroxyproline[J]. Science, 1981, 212 (4498):1038-1040.[9]J. Herber Waitet. Evidence for a repeating 3,4-dihydroxyphenylalaninecontaining and hydroxyproline-containing decapeptide in the adhesive protein of the mussel Mytilus edulis[J]. Journal of Biological Chemistry, 1983, 258 (5):2911-2915.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
