<?xml version="1.1" encoding="utf-8"?>
<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">CDCST</journal-id><journal-title-group><journal-title>China Daily Chemical Science Technology</journal-title></journal-title-group><issn>2997-7096</issn><eissn>2997-710X</eissn><publisher><publisher-name>Art and Technology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/CDCST.2026010019</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>玫瑰PDRN的提取及其抗衰修护功效研究</title><url>https://artdesignp.com/journal/CDCST/3/1/10.61369/CDCST.2026010019</url><author>徐梦详,付冰清,王苗苗,张丽华,陈燕青,赵忻艺</author><pub-date pub-type="publication-year"><year>2026</year></pub-date><volume>3</volume><issue>1</issue><history><date date-type="pub"><published-time>2026-03-05</published-time></date></history><abstract>文章针对玫瑰中多聚脱氧核糖核苷酸（PDRN）开展提取工艺研究并探究其抗衰修护功效。通过冻干-研磨预处理、酶解破壁、Sevag 法除杂及乙醇沉淀分步提取，获玫瑰 PDRN 粗品，得率（5&amp;plusmn;0.08）mg/g。抗衰实验显示，其可显著促进人皮肤成纤维细胞增殖，上调 COL1A1、COL3A1 表达，下调 MMP-1 表达，且显著降低 DPPH 水平（P&amp;lt;0.05）；修护实验表明，其能显著促进 HaCaT 细胞迁移（P&amp;lt;0.01）。文章建立玫瑰 PDRN 标准化提取流程，为其在抗衰修护类化妆品中的应用提供了功效依据。</abstract><keywords>玫瑰,多聚脱氧核糖核苷酸（PDRN）,提取工艺,抗衰,修护</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>[1]吴赟, 张广献. 3组美容多肽复配中各单肽间功效的相互影响[J]. 广州化工, 2021, 49(09): 77-80.[2]FISHER G J, WANG B, CUI Y, et al. Skin aging from the perspective of dermal fibroblasts: the interplay between the adaptation to the extracellular matrix microenvironment and cell autonomous processes [J]. J Cell Commun Signal, 2023, 17(3): 523-9.[3]CHEN H, LI R, ZHAO F, et al. Betulinic acid increases lifespan and stress resistance via insulin/IGF-1 signaling pathway in Caenorhabditis elegans [J]. Front Nutr, 2022, 9: 960239.[4]FAN X, FAN Z, YANG Z, et al. Flavonoids-Natural Gifts to Promote Health and Longevity [J]. Int J Mol Sci, 2022, 23(4).[5]ZHOU Y, ZENG X, LI G, et al. Inactivation of endothelial adenosine A(2A) receptors protects mice from cerebral ischaemia-induced brain injury [J]. Br J Pharmacol, 2019, 176(13): 2250-63.[6]COLANGELO M T, GALLI C, GUIZZARDI S. The effects of polydeoxyribonucleotide on wound healing and tissue regeneration: a systematic review of the literature [J]. Regen Med, 2020, 15(6): 1801-1821.[7]HWANG K H, KIM J H, PARK E Y, et al. An effective range of polydeoxyribonucleotides is critical for wound healing quality [J]. Mol Med Rep, 2018, 18(6): 5166-72.[8]VERONESI F, DALLARI D, SABBIONI G, et al. Polydeoxyribonucleotides (PDRNs) From Skin to Musculoskeletal Tissue Regeneration via Adenosine A(2A) Receptor Involvement [J]. J Cell Physiol, 2017, 232(9): 2299-307.[9]CHAE D, OH S W, CHOI Y S, et al. First Report on Microbial-Derived Polydeoxyribonucleotide: A Sustainable and Enhanced Alternative to Salmon-Based Polydeoxyribonucleotide [J]. Curr Issues Mol Biol, 2025, 47:1.[10]帕尔哈提&amp;middot;柔孜, 阿依姑丽&amp;middot;艾合麦提, 朱昆, 等. 玫瑰花瓣总黄 酮和总多糖的体外抗氧化活性 [J]. 食品科学, 2013, 34(11): 138-41.[11]ALI M K, ASHRAF A, BISWAS N N, et al. Antinociceptive, anti- inflammatory and antidiarrheal activities of ethanolic calyx extract of Hibiscus sabdariffa Linn. (Malvaceae) in mice [J]. Zhong Xi Yi Jie He Xue Bao, 2011, 9(6): 626-31.[12]CHEN F, SU L, HU S, et al. A chromosome-level genome assembly of rugged rose (Rosa rugosa) provides insights into its evolution, ecology, and floral characteristics [J]. Hortic Res, 2021, 8(1): 141.[13]PIOVESAN A, PELLERI M C, ANTONAROS F, et al. On the length, weight and GC content of the human genome [J]. BMC Res Notes, 2019, 12(1): 106.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
