[1]H. Javid, M.A. Oryani, N. Rezagholinejad, et al.RGD peptide in cancer targeting: Benefits, challenges, solutions, and possible integrin– RGD interactions[J]. Cancer Medicine , 2024,13(2): e6800.[2]M. Barczyk, S. Carracedo, D. Gullberg, Integrins[J]. Cell Tissue Res,2010, 339:269–280.[3]B. Bogdanović, D. Fagret, C. Ghezzi, et al. Integrin Targeting and Beyond: Enhancing Cancer Treatment with Dual-Targeting RGD (Arginine–Glycine–Aspartate) Strategies[J].Pharmaceuticals,2024,17:1556.[4]M. Li, Y. Wang, M. Li, et al. Integrins as attractive targets for cancer therapeutics[J]. Acta Pharmaceutica Sinica B,2021, 11:2726–2737.[5]Z. Liu , L.Yu , X. Wang , et al. Integrin (αvβ3) Targeted RGD Peptide Based Probe for Cancer Optical Imaging[J]. Curr Protein Pept Sci, 2016,17(6):570-81.[6]S. Lorenzoni, C. Rodríguez-Nogales, M.J. Blanco-Prieto. Targeting tumor microenvironment with RGD-functionalized nanoparticles for precision cancer therapy[J]. Cancer Letters,2025, 614:217536.[7]李娜.环形/线性RGD序列短肽与整合素αvβ3的反应动力学机制研究[D]. 华南理工大学,2016. [8]苏晴.靶向肽联合聚乙二醇化修饰的新型cRGD-PEG-siRNA分子肿瘤靶向作用及其生物分布研究[D]. 南方医科大学,2023.[9]H. Kuang, S.H. Ku, E. Kokkoli. The design of peptide-amphiphiles as functional ligands for liposomal anticancer drug and gene delivery[J].Advanced Drug Delivery Reviews,2017:110–111.[10]Sonali, R.P. Singh, G. Sharma, et al. RGD-TPGS decorated theranostic liposomes for brain targeted delivery[J]. Colloids and Surfaces B: Biointerfaces ,2016,147:129–141.[11]T. Ji, S. Li, Y. Zhang, et al. An MMP-2 Responsive Liposome Integrating Antifibrosis and Chemotherapeutic Drugs for Enhanced Drug Perfusion and Efficacy in Pancreatic Cancer[J]. ACS Appl. Mater.Interfaces, 2016,8:3438–3445.[12]Z. Belhadj, M. Ying, X. Cao, et al. Design of Y-shaped targeting material for liposome-based multifunctional glioblastoma-targeted drug delivery[J]. Journal of Controlled Release, 2017, 255:132–141.[13]Y. Liu, L. Mei, Q. Yu, et al. Multifunctional Tandem Peptide Modified Paclitaxel-Loaded Liposomes for the Treatment of Vasculogenic Mimicry and Cancer Stem Cells in Malignant Glioma[J].ACS Appl. Mater. Interfaces, 2015, 7:16792–16801. [14]J. Das Neves, R. Nunes, A. Machado, et al. Polymer-based nanocarriers for vaginal drug delivery[J]. Advanced Drug Delivery Reviews, 2015, 92:53–70.[15]C. Li, W. Wang, Y. Xi, et al. Design, preparation and characterization of cyclic RGDfK peptide modified poly(ethylene glycol)-block-poly(lactic acid) micelle for targeted delivery[J].Materials Science and Engineering: C, 2016,64: 303–309.[16]H. Ruan, X. Chen, C. Xie, et al. Stapled RGD Peptide Enables Glioma-Targeted Drug Delivery by Overcoming Multiple Barriers[J].ACS Appl. Mater. Interfaces, 2017 ,9: 17745–17756.[17]F. Arnesano, M.I. Nardella, G. Natile. Platinum drugs, copper transporters and copper chelators[J]. Coordination Chemistry Reviews ,2018, 374:254–260.[18]B. Wang, D. Tang, J. Cui, et al. RGD-based self-assembling nanodrugs for improved tumor therapy[J]. Front. Pharmacol, 2024, 15: 1477409.[19]F. Wang, Y. Li, Y. Shen, et al., The Functions and Applications of RGD in Tumor Therapy and Tissue Engineering[J]. IJMS, 2013, 14:13447–13462.[20]Y. Sun, C. Kang, F. Liu, et al. RGD Peptide ‐Based Target Drug Delivery of Doxorubicin Nanomedicine[J].Drug Development Research, 2017, 78: 283–291.[21]文雪君,周吴昊,郭志德, 等.整合素αvβ3靶向放射性药物99mTc-RGD联合抗PD-L1抗体增强肿瘤治疗效果的研究[J].协和医学杂志,2023,14(04):766-773.[22]E. Apostolova, P. Lukova, A. Baldzhieva, et al. Immunomodulatory and Anti-Inflammatory Effects of Fucoidan: A Review[J]. Polymers, 2020, 12: 2338.[23]E.J. Park, Y. Yuki, H. Kiyono, et al., Structural basis of blocking integrin activation and deactivation for anti-inflammation[J]. J Biomed Sci, 2015, 22: 51.[24]G.A. Koning, R.M. Schiffelers, M.H.M. Wauben, et al. Targeting of angiogenic endothelial cells at sites of inflammation by dexamethasone phosphate–containing RGD peptide liposomes inhibits experimental arthritis[J]. Arthritis & Rheumatism, 2006, 54: 1198–1208.[25]S. Zhang, G. Ge, Y. Qin, et al. Recent advances in responsive hydrogels for diabetic wound healing[J]. Materials Today Bio, 2023,18: 100508.[26]H. Chen, N. Xue, Y. Zhang, et al. Robust visible-infrared image matching by exploiting dominant edge orientations[J]. Pattern Recognition Letters, 2019, 127: 3–10.[27]L. Duan, G. Liu, F. Liao, et al. Antheraea pernyi silk nanofibrils with inherent RGD motifs accelerate diabetic wound healing: A novel drug-free strategy to promote hemostasis, regulate immunity and improve re-epithelization[J]. Biomaterials, 2025, 318: 123127.[28]L. Wu, Y. Kim, G.M. Seon, et al. Effects of RGDgraf ted phosphat idylser ine-containing liposomes on the polarization of macrophages and bone tissue regeneration[J]. Biomaterials,2021,279:121239.[29]J.-S. Bae, J.M. Kim, J.Y. Kim, et al. Topical application of palmitoyl-RGD reduces human facial wrinkle formation in Korean women[J]. Arch Dermatol Res,2017,309:665–671.[30]S.Y. Shin, N.R. Song, M.H. Lee, et al. Galloyl–RGD, Derived from a Fusion of Phytochemicals and RGD Peptides, Regulates Photoagingvia the MAPK/AP-1 Mechanism in Human Dermal Fibroblasts[J].Cosmetics,2024,11:171.